NF2 and vestibular schwannoma

NF2 is the gene encodes Merlin, a tumor suppressor protein. Mutations in NF2, both inherited or spontaneous, lead to NF2-related schwannomatosis, which is characterized by bilateral vestibular schwannomas. To further understand the mechanisms and better develop the therapeutic strategies, we utilize the human stem cell-derived Schwann cell model to study NF2-related schwannomatosis.